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San Mateo County, California locator map According to the United States Census Bureau, South San Francisco is a City that is located in San Mateo County, California at 37.65 degrees North and 122.41 degrees West.  The city's time zone is America/Los Angeles, and the city's primary telephone area code is 650.  The land area of South San Francisco is about 9.18 square miles, whereas the water area of the city is about 21.02 square miles.  San Mateo County's land area is about 448 square miles, so the city occupies about 2.0 percent of the county's total land area.

The Census Bureau estimates that South San Francisco had about 67,429 residents in 2017, which is approximately 7,345 people per square mile of land area. 

According to recent American Community Survey data, South San Francisco had 21,470 total estimated households and the median household income was about $78,101 per year. 

The California counties map at upper right shows San Mateo County, highlighted in red.  Use the menu below to display interactive maps of South San Francisco, either in a frame on this page or in full-screen mode. 

South San Francisco, California Maps

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